세포에서 CNNM4의 발현을 억제하기 위한 핵산

• Main Authors: DAMES SIBYLLE, DE LA CRUZ ALFONSO MARTINEZ, CHANTAR MARIA LUZ MARTINEZ, RECIO IRENE GONZALEZ, SCHAEPER UTE, SCHUBERT STEFFEN, ESPINOSA JORGE SIMON
• Format: Patent
• Language: Korean
• Published: 07.02.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 CNNM4(사이클린 M4) 유전자 발현을 방해하거나 억제하는 핵산 생성물에 관한 것이다. 또한 비-알코올성 지방간 질환 (NAFLD), 비-알코올성 지방간염 (NASH), 간 지방증, 간 섬유증, 간경변증, 간암 및 마그네슘 조절장애와 연관된 다른 질환을 포함하여 간 질환과 같은 질환의 치료에서의 CNNM4 억제의 치료적 용도에 관한 것이다. The invention relates to nucleic acid products that interfere with or inhibit CNNM4 (Cyclin M4) gene expression. It further relates to therapeutic uses of CNNM4 inhibition for the treatment of diseases, such as liver diseases including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver steatosis, liver fibrosis, liver cirrhosis, liver cancer and other diseases associated with magnesium dysregulation.