외인성 단백질의 생산을 위한 변형된 사상균

• Main Authors: SALOHEIMO MARKKU, VITIKAINEN MARIKA, HUUSKONEN ANNE, KOVALCHUK ANDRIY, TCHELET RONEN, EMALFARB MARK AARON, LANDOWSKI CHRISTOPHER
• Format: Patent
• Language: Korean
• Published: 25.01.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은, KEX2 및/또는 ALP7의 감소된 활성 또는 발현을 갖는, 특히 써모텔로마이세스 헤테로탈리카 종의 유전자 변형된 자낭균성 사상균에 관한 것이고, 상기 사상균은 외인성 단백질의 높은 양 및 안정성을 생성할 수 있다. The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, having reduced activity or expression of KEX2 and/or ALP7, said filamentous fungi is capable of producing elevated amounts and stability of an exogenous protein.