SHP2 SHP2 INHIBITORS AND USE THEREOF

Provided are an SHP2 inhibitor, a pharmaceutical composition for preventing or treating SHP2-related diseases including the same, a method for treating and preventing diseases using the same, and uses thereof. According to the same, diseases related to SHP2 can be effectively prevented or treated. O...

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Main Authors KIM DONGSU, JANG SOYEON, KIM MIYEON, LEE KANGWOO, PARK DOHYUN, LIM SANG KYUN, LEE MIJUNG, KIM EUNJI, JEON DAHYE, LEE KYUNGIK, CHUNG EU DDEUM, MIN JIEUN, YOON KYEONGJIN, KIM JINHWAN, CHOI SUNGPIL, YOO JAKYUNG
Format Patent
LanguageEnglish
Korean
Published 20.01.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are an SHP2 inhibitor, a pharmaceutical composition for preventing or treating SHP2-related diseases including the same, a method for treating and preventing diseases using the same, and uses thereof. According to the same, diseases related to SHP2 can be effectively prevented or treated. One aspect provides a compound represented by chemical formula 1A below, a stereoisomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. SHP2의 저해제, 이를 포함하는 SHP2와 관련된 질환의 예방 또는 치료용 약학적 조성물, 이를 이용한 질병의 치료 및 예방 방법, 및 이의 용도를 제공한다. 이에 의하면, SHP2와 관련된 질환을 효과적으로 예방 또는 치료할 수 있다.
Bibliography:Application Number: KR20220084532