DIAGNOSIS AND THERAPY OF CANCER INVOLVING CANCER STEM CELLS

• Main Authors: HAECKER SABINE, TUERECI OEZLEM, KREUZBERG MARIA, JACOBS STEFAN, WALTER KORDEN, SAHIN UGUR, WAGNER MEIKE
• Format: Patent
• Language: English; Korean
• Published: 12.01.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

본 발명은 CLDN6을 표적화하는 것을 포함하는 암 줄기세포와 연관된 암 질환의 진단 또는 치료 방법을 제공한다. 특히, 본 발명은 CLDN6을 발현하는 세포를 검색하는 것을 포함하는, 암 줄기세포의 탐지 방법을 제공한다. 뿐만 아니라, 본 발명은 CLDN6에 결합하는 능력이 있는 항체를 암 환자에게 투여함으로써 암 줄기세포를 억제 및/또는 제거하는 것을 포함하는 암의 치료 또는 예방 방법을 제공한다. The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.