METHOD OF PREPARING INTERMEDIATES FOR SYNTHESIZING XANTHINE OXIDASE INHIBITOR

The present invention relates to a preparation method of an intermediate for synthesizing a xanthine oxidase inhibitor, and more specifically, to a preparation method of compounds of following formula 2 and following formula 4 using an inexpensive starting material and ligand and chelating extractio...

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Bibliographic Details
Main Authors JEONG HUI RAK, PARK AH BYEOL, LEE SEOK JU, KIM KI DAE, LEE JU YEOL
Format Patent
LanguageEnglish
Korean
Published 10.01.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a preparation method of an intermediate for synthesizing a xanthine oxidase inhibitor, and more specifically, to a preparation method of compounds of following formula 2 and following formula 4 using an inexpensive starting material and ligand and chelating extraction and purification technique. In the formulas, X, R1, R2, R3, R4, and R5 are as the same as defined in the specification. The preparation method of the present invention can secure economic feasibility and effectively reduce residual impurity by replacing expensive Cs2CO3 previously used in the preparation of the compound of formula 2 with dramatically cheaper KOH. 본 발명은 잔틴 옥시다아제 저해제 합성을 위한 중간체의 제조 방법에 관한 것으로, 보다 상세하게는 저가의 출발물질 및 리간드, 킬레이팅 추출 정제기법을 사용하는 하기 화학식 2 및 화학식 4 화합물을 제조하는 방법에 관한 것이다: [화학식 2] JPEGpat00039.jpg2636 [화학식 4] JPEGpat00040.jpg3955 상기 식에서 X, R1, R2, R3, R4 및 R5는 명세서에 정의되어 있는 바와 같다.
Bibliography:Application Number: KR20220081195