METHODS AND COMPOSITIONS FOR REDUCING IMMUNOSUPRESSION BY TUMOR CELLS

• Main Authors: CANTOR HARVEY I, ALVAREZ ARIAS DIANA, SHAFFER DONALD, ZHOU PENGHUI, WUCHERPFENNIG KAI W, HACOHEN NIR, DRANOFF GLENN
• Format: Patent
• Language: English; Korean
• Published: 09.01.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 개시내용은 부분적으로, 생체내에서 면역요법 표적을 발견하는 방법, 치료 조성물 (예를 들어, shRNA, shRNA를 발현하는 면역반응성 세포 및/또는 키메라 항원 수용체 (CAR)), 및 그의 사용 방법을 제공한다. The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.