ASM PHARMACEUTICAL COMPOSITION FOR TREATING OF BRAIN DIEASES COMPRISING ANTIBODIES SPECIFICALLY BINDING TO ASM PROTEIN

• Main Authors: JIN HEEKYUNG, HONG SEUNGBEOM, BAE JAESUNG
• Format: Patent
• Language: English; Korean
• Published: 06.12.2022
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a use of an antibody specifically binding to acid sphingomyelinase (ASM) protein. Specifically, the antibody or an antigen binding fragment thereof according to the present invention specifically binds to the ASM protein with high binding capacity, significantly inhibits the activity of the ASM protein existing in a cellular membrane, and exhibits an effect of improving cognitive memory, an effect of inhibiting the ASM protein activity, an effect of inhibiting the accumulation of amyloid-β and tau proteins, and an effect of inhibiting nerve inflammation occurrence, thereby being able to usefully used in treating brain diseases. 본 발명은 ASM(acid sphingomyelinase) 단백질에 특이적으로 결합하는 항체의 용도에 관한 것이다. 구체적으로, 본 발명에 따른 항체 또는 이의 항원 결합 단편은 ASM 단백질에 특이적으로 높은 결합력으로 결합하고, 세포막에 존재하는 ASM 단백질의 활성을 유의적으로 억제하며, 알츠하이머 동물 모델에서 독성을 나타내지 않으면서 인지 기억력 개선 효과, ASM 단백질 활성 억제 효과, 아밀로이드-β 및 타우 단백질 축적 억제 효과, 및 신경염증 생성 억제 효과를 나타냄으로써, 뇌질환의 치료에 유용하게 사용될 수 있다.