Benzamide derivatives preparation method thereof and pharmaceutical composition for use in preventing or treating cancer containing the same as an active ingredient

• Main Authors: YOON DASEUL, JO HYE IM, LEE KWANGHO, CHOI SEONG IL, KANG SEOCKYONG, BYEON YEJI, JUNG SEUNG HEE, LEE SEUNG CHUL, KIM DONGKYU, PARK JI YEON, KIM HYEJEONG, PARK SOM YI
• Format: Patent
• Language: English; Korean
• Published: 25.11.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a benzamide derivative, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient, wherein the benzamide derivative provided in one aspect of the present invention inhibits EGFR mutation to prevent or treat cancer, and when administered in combination with an EGFR antagonist such as cetuximab, thereby being usefully used as an anticancer agent due to a remarkable synergistic effect in terms of anticancer activity. 벤즈아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명의 일 측면에서 제공하는 벤즈아미드 유도체는 EGFR 돌연변이를 억제하여 암의 예방 또는 치료에 사용될 수 있고, 세툭시맙(Cetuximab) 등의 EGFR 길항제와 병용투여될 경우 항암활성 측면에서 현저한 상승(synergy) 효과가 나타나 항암제로 유용하게 사용될 수 있다.