HIF-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물

• Main Authors: JACOB STEVEN DONALD, LAWSON KENNETH VICTOR, GUNEY TEZCAN, MATA GUILLAUME, WANG ZHANG, JEFFREY JENNA LEIGH, SU YONGLI, MANDAL DEBASHIS, MOON HYUNYOUNG, HAELSIG KARL T, GAL BALINT, MAILYAN ARTUR KARENOVICH, EPPLIN MATTHEW, ROSEN BRANDON REID, LINDSEY ERICK ALLEN, HARDMAN CLAYTON, BEATTY JOEL WORLEY, FOURNIER JEREMY THOMAS ANDRE, YAN XUELEI, POWERS JAY PATRICK, DREW SAMUEL LAWRIE, YU KAI, KALISIAK JAROSLAW, TRAN ANH THU, LELETI MANMOHAN REDDY
• Format: Patent
• Language: Korean
• Published: 23.11.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

HIF-2α를 억제하는 화합물, 및 화합물(들)을 함유하는 조성물 및 화합물을 합성하는 방법이 본원에 기재된다. 또한, 적어도 부분적으로 HIF-2α에 의해 매개되는 암- 및 면역-관련 장애를 비롯한 다양한 질환, 장애 및 상태의 치료를 위한 이러한 화합물 및 조성물의 용도가 기재된다. TIFFpct00241.tif2733 Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.