1- PHARMACEUTICAL COMPOSITION FOR TABLETING BY DIRECT COMPRESSION COMPRISING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST

• Main Authors: HAN HAE JU, YUN DUCK IL, MIN HYUN HONG, LEE SI NAE
• Format: Patent
• Language: English; Korean
• Published: 21.10.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a directly compressible pharmacological composition comprising a sphingosine-1-phosphate receptor agonist and, more specifically, to a pharmacological composition for direct compression, comprising 1-[1-chloro-6-(3-chloro-1-isopropyl-1H-indazol-5-ylmethoxy)-3,4-dihydro-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid of formula 1 or a pharmacologically acceptable salt thereof as an active ingredient, and comprising lactose or a hydrate thereof as a diluent, hydroxypropyl cellulose as a binder, sodium stearyl fumarate as a lubricant, and croscarmellose sodium as an excipient. The composition can be prepared by direct compression method with stability secured. 본 발명은 스핑고신-1-인산 수용체 효능제를 포함하는 직접 타정용 약제학적 조성물에 관한 것으로, 보다 상세하게는 유효성분으로 하기 화학식 1의 1-[1-클로로-6-(3-클로로-1-아이소프로필-1H-인다졸-5-일메톡시)-3,4-디하이드로-나프탈렌-2-일메틸]-피페리딘-4-카르복실산 또는 이의 약제학적으로 허용되는 염, 희석제로 락토오스 또는 이의 수화물, 결합제로 하이드록시프로필 셀룰로오스, 활택제로 소듐 스테아릴 푸마레이트 및 붕해제로 크로스카멜로오스나트륨을 포함하는 직접 타정을 위한 약제학적 조성물에 관한 것이다: [화학식 1] JPEGpat00016.jpg3792