MLL INHIBITORS OF THE MENIN-MLL INTERACTION

본 발명은 메닌과 MLL 및 MLL 융합 단백질의 상호 작용의 억제제, 이를 함유하는 약학적 조성물, 및 메닌-MLL 상호 작용에 의해 매개되는 암 및 다른 질환의 치료에서 이들의 용도에 관한 것이다. The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatme...

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Main Authors MARCUS ANDREW, LOTESTA STEPHEN D, HOUSTON TRAVIS L, MORALES RAMOS ANGEL, ZHENG YAJUN, ZHUANG LINGHANG, JIA LANQI, PARENT STEPHAN D, CLAREMON DAVID A, FAN YI, YUAN JING, CACATIAN SALVACION, DONG CHENGGUO, SINGH SURESH B, DILLARD LAWRENCE WAYNE, VENKATRAMAN SHANKAR
Format Patent
LanguageEnglish
Korean
Published 08.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:본 발명은 메닌과 MLL 및 MLL 융합 단백질의 상호 작용의 억제제, 이를 함유하는 약학적 조성물, 및 메닌-MLL 상호 작용에 의해 매개되는 암 및 다른 질환의 치료에서 이들의 용도에 관한 것이다. The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
Bibliography:Application Number: KR20227028964