HUMAN ALPHA-GALACTOSIDASE VARIANTS

• Main Authors: HUISMAN GJALT W, MILLER MATHEW G, ZHANG XIYUN, AGARD NICHOLAS J
• Format: Patent
• Language: English; Korean
• Published: 06.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 조작된 인간 알파-갈락토시다제 폴리펩티드 및 그의 조성물을 제공한다. 조작된 인간 알파-갈락토시다제 폴리펩티드는 산성(pH <4.5) 및 염기성(pH >7) 조건, 둘 모두에서 개선된 안정성을 제공하도록 최적화된 것이다. 본 발명은 또한 치료학적 목적의, 조작된 인간 알파-갈락토시다제 폴리펩티드를 포함하는 조성물의 용도에 관한 것이다. The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH <4.5) and basic (pH >7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.