E8,E10-도데카디에닐 코엔자임 A, 코들레몬 및 이의 유도체를 생산하기 위한 효모 세포 및 방법

• Main Authors: BORODINA IRINA, LOEFSTEDT CHRISTER, DING BAOJIAN, WENNING LEONIE, HOLKENBRINK CARINA
• Format: Patent
• Language: Korean
• Published: 25.08.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

본 발명은 E8,E10-도데카디에닐 코엔자임 A, 코들레몬 (E8,E10-도데카디엔-1-올), 및 임의로, 이의 유도체 E8,E10-도데카디에닐 아세테이트 및/또는 E8,E10-도데카디에날의 생산을 위해 조작된 효모 세포에 관한 것이다. E8,E10-도데카디에닐 코엔자임 A, 코들레몬 (E8,E10-도데카디엔-1-올), 및 임의로, 이의 유도체 E8,E10-도데카디에닐 아세테이트 및/또는 E8,E10-도데카디에날의 생산 방법 또한 제공한다. 상기 효모 세포를 수득하는 데 유용한 핵산 구축물 또한 제공한다. The present invention relates to yeast cells engineered for the production of E8,E10-dodecadienyl coenzyme A, codlemone (E8,E10-dodecadien-1-ol), and optionally its derivatives E8,E10-dodecadienyl acetate and/or E8,E10-dodecadienal. Methods for production of E8,E10-dodecadienyl coenzyme A, codlemone (E8,E10-do-decadien-1-ol), and optionally its derivatives E8,E10-dodecadienyl acetate and/or E8,E10-dodecadienal are also provided. Nucleic acid constructs useful for obtaining such yeast cells are also provided.