METHODS OF TISSUE GENERATION

• Main Authors: HOFGARTNER WOLFGANG, YE QIAN, HARIRI ROBERT J, BHATIA MOHIT B, WANG JIA LUN
• Format: Patent
• Language: English; Korean
• Published: 05.07.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 표면 위에 세포 및 세포외 기질을 침착시키는 것을 포함하는, 시험관내 또는 생체외에서 조직 및 기관을 생성하는 방법, 및 상기 조직 및 기관의 사용 방법에 관한 것이다. 한 태양에서, 본원에 기술된 조직(예를 들면, 3-차원 조직) 및 기관을 생성하는 방법에 따라 사용되는 세포 및 ECM은 동일 조성물의 일부로서 침착된다. 또 다른 태양에서, 본원에 기술된 조직(예를 들면, 3-차원 조직) 및 기관을 생성하는 방법에 따라 사용되는 세포 및 ECM은 상이한 조성물의 일부로서 침착된다. Provided herein are methods of generating tissues and organs in vitro or ex vivo comprising depositing cells and ex-tracellular matrix onto a surface, as well as methods of using such tissues and organs. In one embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g. three-dimensional tissues) and organs described herein and deposited as part of the same composition. In another embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g. three-dimensional tissues) and organs described herein are deposited as part of different compositions.