프로스타글란딘 아날로그 및 이들의 용도

• Main Authors: YOON CHEOLHWAN, YOO JUN YEOB, HAN CHEOLKYU, RAJAN SREEKANTH, YOON HO SUP, SEO JEONGBEOB, KANG HONGJUN, KIM MOONHWAN
• Format: Patent
• Language: Korean
• Published: 05.07.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 프로스타글란딘 아날로그 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, Nurr1과 관련된 질환, 장애 또는 상태의 예방 또는 치료용 약학적 조성물로서, 상기 화합물은 Nurr1을 유도함에 있어 탁월한 효과를 가지고, 따라서 Nurr1과 관련된 질병, 장애 또는 상태, 특히 암, 류마티스 관절염과 같은 자가면역 질환, 정신분열증, 조울증 및 예컨대 알츠하이머병이나 파킨슨병과 같은 신경퇴행성 질환에 유용하다. The present invention relates to pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, including, as an active ingredient, a prostaglandin analog or a pharmaceutically acceptable salt thereof, wherein the compound has excellent effects in inducing Nurr1, and thus, can be useful as a pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, in particular, cancer, autoimmune disease such as rheumatoid arthritis, schizophrenia, manic depression and neurodegenerative disease such as Alzheimers disease or Parkinson's disease.