신규 치환 축환형 화합물

• Main Authors: KOIKE SACHIKO, IKUMA YOHEI, FUKAYA TAKAYUKI, UESUGI SHUNICHIRO
• Format: Patent
• Language: Korean
• Published: 28.06.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은, 우수한 β-락타마제 저해 작용을 갖는 신규 화합물을 제공한다. 본 발명은, 우수한 β-락타마제 저해 작용을 갖는 식 (1a), (1b) 또는 (11)로 표시되는 화합물 또는 그의 제약학적으로 허용되는 염을 제공한다. 이 화합물은, β-락탐계 약제와의 병용 혹은 단제로 세균 감염증의 유용한 예방 또는 치료제를 제공한다. 본 발명은 또한, 여러 질환의 β-락탐계 약제와의 병용에 의한 치료를 위해 유용한 예방 또는 치료제를 제공한다. The present invention provides a novel compound having an excellent β-lactamase inhibitory effect. The present invention provides: a compound which has an excellent β-lactamase inhibitory effect, and is represented by formula (1a), (1b) or (11); or a pharmaceutically acceptable salt thereof. This compound provides a prophylactic or therapeutic agent effective for bacterial infections when used in combination with β-lactam-based drugs or used as a single agent. The present invention also provides a prophylactic or therapeutic agent effective for treating various diseases, by being used in combination with β-lactam-based drugs.