Hyaluronate Fiber and Manufacturing Method Thereof

• Main Authors: HONG JOO YEON, KWON SIN HWAN, KIM JONG SOO, LEE HYUN HO, KWEON DONG KEON, JEON YOUNG CHAN, LI DA WEI, LEE MYOUNG HAN
• Format: Patent
• Language: English; Korean
• Published: 03.06.2022
• Subjects: APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS; DIAGNOSIS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NATURAL OR ARTIFICIAL THREADS OR FIBRES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPINNING; SURGERY; TEXTILES

본 발명은 히알루론산염 파이버 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 수술용 봉합사, 리프팅용 실, 조직공학용 지지체 등으로 활용 가능한 고강도 히알루론산염 파이버 및 이의 제조방법에 관한 것이다. 본 발명에 따른 히알루론산염 파이버의 제조방법은 (a) 중량평균 분자량이 100∼3,000kDa인 히알루론산염의 수분함량을 50∼95중량%로 조절하여 히알루론산염 페이스트(paste)를 제조하는 단계; (b) 수분함량이 조절된 히알루론산염 페이스트(paste)를 상온∼100℃로 승온 가열 후, 노즐을 통해 압출시키는 단계; 및 (c) 압출된 방사유체를 건조시켜 파이버를 형성하는 단계를 포함한다. 본 발명의 히알루론산염 파이버는 수분함량이 5~25중량%이고, 인장강도가 3~15kg/㎟이며, 표면의 크랙이 적고 매끄럽기 때문에 수술용 봉합사, 리프팅용 실, 성형 필러, 조직공학용 지지체 등의 용도로 적용이 가능하다. The present invention relates to a hyaluronate fiber and a manufacturing method therefor and, more specifically, to a high-strength hyaluronate fiber utilizable as a surgical suture, a thread for lifting, a support for tissue engineering, and the like, and to a manufacturing method therefor. The manufacturing method for a hyaluronate fiber according to the present invention comprises the steps of: (a) adjusting the moisture content of hyaluronate having a weight average molecular weight of 100-3,000 kDa to 50-95 wt% to prepare a hyaluronate paste; (b) heating the hyaluronate paste with an adjusted moisture content to raise the temperature to room temperature to 100°C, followed by extrusion through a nozzle; and (c) drying the extruded spinning fluid to form a fiber. The hyaluronate fiber of the present invention shows a moisture content of 5-25 wt% and a tensile strength of 3-15kg/㎟ and has a smooth surface with few cracks, and thus can be applied to a surgical suture, a thread for lifting, a cosmetic filler, a support for tissue engineering, and the like.