SELECTIVE DELIVERY OF MATERIAL TO CELLS

• Main Authors: LANGER ROBERT S, JENSEN KLAVS F, ADALSTEINSSON VIKTOR A, SHAREI ARMON R, LOVE J. CHRISTOPHER, CHO NAHYUN
• Format: Patent
• Language: English; Korean
• Published: 20.04.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; SPIRITS; TESTING; TRANSPORTING; VINEGAR; WINE

세포의 물리적 성질을 기반으로 세포를 분리 또는 식별하는 것은 세포 현탁액을 제공하는 것; 상기 세포 현탁액을 협착부를 포함하는 미세 유체 채널을 통하여 통과시키는 것; 및, 상기 세포 현탁액 용액을 화합물과 접촉시키는 것을 포함한다. 이 협착부는 상대적으로 더 작은 세포와 비교해서 상대적으로 더 큰 세포를 우선적으로 변형하기 위해 크기화 될 수 있다. Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.