[1,2,4]트리아졸로[1,5-c]퀴나졸린-5-아민

• Main Authors: BADER BENJAMIN, GUENTHER JUDITH, ZORN LUDWIG, MEIER ROBIN MICHAEL, GUTCHER ILONA, BAUMANN DANIEL, BUCHMANN BERND, SCHMEES NORBERT, GORJANACZ MATYAS, HERBERT SIMON ANTHONY, STOECKIGT DETLEF, PLATTEN MICHAEL, LEFRANC JULIEN, KOBER CHRISTINA, BOTHE ULRICH, BOEHME STEPHAN, ROESE LARS
• Format: Patent
• Language: Korean
• Published: 13.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 화학식 (I)의 [1,2,4]트리아졸로[1,5-c]퀴나졸린-5-아민 화합물, 상기 화합물의 제조 방법, 상기 화합물을 제조하는데 유용한 중간체 화합물, 상기 화합물을 포함하는 제약 조성물 및 조합물, 및 질환, 특히 조절이상 면역 반응을 갖는 암 또는 상태, 또는 이상 AHR 신호전달과 연관된 다른 장애의 치료 또는 예방을 위한 제약 조성물을 단독 작용제로서 또는 다른 활성 성분과 조합하여 제조하기 위한 상기 화합물의 용도를 포함한다: JPEGpct01246.jpg3845 여기서 R1, R2, R3, R4, R5, R6, R7 및 R8은 상기 정의된 바와 같다. The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.