MODIFIED RNA ENCODING VEGF-A POLYPEPTIDES FORMULATIONS AND USES RELATING THERETO

• Main Authors: HANSSON KENNY MIKAEL, CHIEN KENNETH RANDALL, GAN LI MING, FRITSCHE DANIELSON REGINA DESIREE, EGNELL ANN CHARLOTTE EVA, CLARKE JONATHAN, PARINDER LEIF KARLSSON
• Format: Patent
• Language: English; Korean
• Published: 29.03.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 개시는 VEGF-A 폴리펩타이드를 인코딩하는 변형된 RNA 분자 및 상기 변형된 RNA를 포함하는 제제에 관한 것이다. 추가로, 본 개시의 양태는 VEGF-A 요법에 반응성인 질병을 앓고 있는 대상체의 치료에 있어서 상기 변형된 RNA를 포함하는 제제의 제조 및 용도에 관한 것이다. The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in treating subjects suffering from diseases responsive to VEGF-A therapy.