Bispecific antibody or antigen-binding fragment thereof and method for preparing the same

• Main Authors: KIM MAENG SUP, JUNG SUNG YOUB, PARK YOUNG JIN, BANG HYO JOO
• Format: Patent
• Language: English; Korean
• Published: 10.03.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are a protein complex having a high heterodimer formation rate, a method for preparing the same, a pharmaceutical composition for preventing or treating cancer which comprises the protein complex, and a method for preventing or treating cancer using the same. Accordingly, a bispecific antibody or an antigen-binding fragment having increased stability, a receptor and a receptor-binding agonist, an antagonist, ligand, cytokine or receptor decoy diconjugate can be easily manufactured and can be used in various fields such as disease prevention or disease treatment, and disease diagnosis. 헤테로다이머 형성률이 높은 단백질 복합체, 이를 제조하는 방법, 단백질 복합체를 포함한 암의 예방 또는 치료용 약학적 조성물, 이를 이용한 암의 예방 또는 치료 방법을 제공한다. 이에 따르면, 증가된 안정성을 갖는 이중특이 항체 또는 항원-결합 단편, 수용체와 수용체에 결합하는 작용제(agonist), 길항제(antagonist), 리간드(ligand), 사이토카인 또는 수용체 유인(decoy) 이중접합체를 쉽게 제조할 수 있고, 질병 예방 또는 치료, 및 질병 진단 등 다양한 분야에 활용 가능하다.