191P4D12 ANTIBODY DRUG CONJUGATES ADC THAT BIND TO 191P4D12 PROTEINS

• Main Authors: MORRISON KAREN JANE MEYRICK, TORGOV MICHAEL, GUDAS JEAN, MORRISON ROBERT KENDALL, AN ZILI, JAKOBOVITS AYA, SATPAEV DAULET
• Format: Patent
• Language: English; Korean
• Published: 03.02.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

191P4D12 단백질 및 그의 변이체에 결합하는 항체 약물 컨쥬게이트(ADC's)가 개시된다. 191P4D12는 정상적인 성인 조직에서 조직 특이적 발현을 나타내며 표 I에 수록된 암에서 비정상적으로 발현된다. 결론적으로, 본 발명의 ADC들은 암 치료를 위한 치료용 조성물을 제공해준다. The present invention provides nucleotides encoding an anti-191P4D12 antibody or antigen binding fragment thereof, vectors comprising the nucleotides, and cells comprising the vectors. The invention further provides methods of producing the antibodies of the invention and its fragments as well as antibody-drug conjugates using the cells of the invention.