B- CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN

• Main Authors: RAJPAL ARVIND, KUO TRACY CHIA CHIEN, VAN BLARCOM THOMAS JOHN, CHAPARRO RIGGERS JAVIER FERNANDO, SASU BARBRA JOHNSON, GALETTO ROMAN, BOLDAJIPOUR BIJAN ANDRE, JUILLERAT ALEXANDRE, VALTON JULIEN, PERTEL THOMAS CHARLES, DUCHATEAU PHILIPPE, SOMMER CESAR ADOLFO
• Format: Patent
• Language: English; Korean
• Published: 21.01.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 BCMA (B-세포 성숙 항원)에 특이적으로 결합하는 키메라 항원 수용체 (CAR)를 제공한다. 본 발명은 추가로 이러한 CAR을 포함하는 조작된 면역 세포, CAR-코딩 핵산, 및 이러한 CAR, 조작된 면역 세포, 및 핵산을 제조하는 방법에 관한 것이다. 본 발명은 추가로 BCMA를 발현하는 악성 세포와 연관된 상태 (예를 들어, 암)의 치료를 위한 이들 CAR 및 조작된 면역 세포의 사용을 위한 치료 방법에 관한 것이다. The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).