Fruits of Acanthopanax Sessiliflorus extract including alcoholic liver injury prevention functional ingredients and method for manufacturing it

• Main Authors: LEE YOUNG SEOB, CHOI DOO JIN, KIM DONG HWI, HAN KYUNG SOOK, YOON DAHYE, LEE DAEYOUNG
• Format: Patent
• Language: English; Korean
• Published: 24.12.2021
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for alcoholic liver injury inhibition containing an acanthopanax sessiliflorus extract as an active ingredient. The acanthopanax sessiliflorus extract, preferably an acanthopanax sessiliflorus fruit extract, protects hepatocytes from ethanol damage-attributable hepatocytotoxicity, lowers the blood concentrations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in an animal model in which liver injury is caused by ethanol administration, and effectively decreases the blood concentration of LDH increased by ethanol administration. Accordingly, the composition of the present invention can be useful as a health functional food for alcoholic liver injury inhibition or an alcoholic liver injury remedy. 본 발명은 오가피 추출물을 유효성분으로 포함하는 알코올성 간 손상 억제용 조성물에 관한 것으로, 상기 오가피 추출물, 바람직하게는 오가피 열매 추출물은 에탄올 손상에 의한 간세포 독성으로부터 간세포를 보호하고, 에탄올 투여에 의해 간 손상을 유발한 동물모델에서 ALT(alanine aminotransferase) 및 AST(aspartate aminotransferase)의 혈중 농도를 저하시키고, 에탄올 투여에 의해 증가된 혈중 LDH 농도를 효과적으로 감소시키는 효과가 우수하므로, 본 발명의 조성물은 알코올성 간 손상 억제용 건강기능식품 또는 알코올성 간 손상 질환의 치료제로 유용하게 사용할 수 있다.