핵산 전달을 위한 혼성 희생 세포-침투 복합체

• Main Authors: WAYMOUTH ROBERT M, BLAKE TIM R, LEVY RONALD, SALLETS ADRIENNE, HAABETH OLE AUDUN WERNER, FRANK MATTHEW, WENDER PAUL
• Format: Patent
• Language: Korean
• Published: 19.10.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 명세서에는 특히 생체내에서 핵산을 세포 내로 전달하기 위한 복합체, 조성물 및 방법이 제공된다. 상기 복합체, 조성물 및 방법은 시험관내 및 생체내에 둘 다에서 표적 세포, 조직 및 장기 내로의 올리고뉴클레오티드 및 다음이온성 카고의 전달 및 방출, 복합체화, 보호를 용이하게 할 수 있다. There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.