부갑상선 호르몬 변이체

• Main Authors: HOLMES KEVIN, NORTON ANGELA, GOODWIN BRYAN, LLOYD DAVID, JAIN SUJIT, SHEN CHUAN, PAN CLARK, SHI RONGXIN
• Format: Patent
• Language: Korean
• Published: 07.10.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 부갑상선 호르몬 (PTH) 변이체, 및 상기를 포함하는 제약 조성물에 관한 것이다. 본 발명은 추가로 혈청 반감기 및 피크-트로프 비가 개선된 PTH 조성물, 및 본 발명의 PTH 변이체 및 조성물을 이용하여 혈청 칼슘 수준을 제어하는 방법에 관한 것이다. 본 발명은 추가로 본 발명의 PTH 변이체 및 조성물을 이용하여 부갑상선기능저하증 및/또는 부갑상선기능저하증에 기인하는 저칼슘혈증을 치료하는 방법에 관한 것이다. The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.