A development of combination therapy for fibrotic diseases

• Main Authors: LEE YOON JIN, KIM KWANG SEOK, LEE HAE JUNE, KIM JIHEE, NAM JAE KYUNG
• Format: Patent
• Language: English; Korean
• Published: 05.10.2021
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a combination composition of metformin and Chir99021 for the treatment of fibrosis. The composition according to the present invention inhibits collagen deposition, inhibits inflammatory response, prevents fibrosis of blood vessels, and prevents tissue damage, thereby having an excellent preventive and therapeutic effect on fibrosis. 본 발명은 섬유증 치료를 위한 메트포민 및 Chir99021의 복합제 조성물에 관한 것이다. 본 발명에 따른 조성물은 콜라겐 침착을 억제하고, 염증 반응을 저해하며, 혈관의 섬유화를 방지하고, 조직 손상을 방지함으로써, 섬유증에 대해 우수한 예방 및 치료 효과를 가진다.