Novel pyrimidine derivatives and composition for preventing or treating neurodegenerative disease and cancer comprising thereof

• Main Authors: SIM SEONG HYEON, SEO JEE YEON, LEE GE HYEONG, LEE JI HUN, SHIN HO CHUL, KANG HEE YEON, HEO JAE KYUNG, YE IN HAE, YOU BYOUNG HOON, SUH JEE HEE, HWANG KEON HA, HAN SONG HEE, CHAE CHONG HAK, KIM SEONG HWAN, YU JEONG HEON, SONG JIN SOOK
• Format: Patent
• Language: English; Korean
• Published: 01.10.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel pyrimidine derivative and a composition for preventing or treating neurodegenerative diseases and cancer comprising the same. The pyrimidine derivative has excellent LRRK2 protein inhibitory activity and efficiently passes through a blood-brain barrier (BBB), and thus can be usefully used as a pharmaceutical composition for the prevention or treatment of neurodegenerative diseases and cancer. 본 발명은 신규한 피리미딘 유도체 및 이를 포함하는 신경퇴행성 질환 및 암의 예방 또는 치료용 조성물에 관한 것으로, 상기 피리미딘 유도체는 LRRK2 단백질 저해 활성이 우수하고, 혈액뇌장벽(BBB)을 효율적으로 통과하여 신경퇴행성 질환 및 암의 예방 또는 치료용 약학 조성물로 유용하게 사용가능하다.