개선된 종양 반응성 T-세포의 선택

본 발명은 증강된 종양-특이적 사멸화 역량(capacity)(예를 들어, 증강된 세포독성)을 갖는 TIL의 치료 집단을 생성하기 위해 PD-1 발현에 기초하여 TIL을 예비선택하는 방법, 뿐만 아니라 이들 예비선택된 PD-1 양성 TIL을 확장시키는 방법을 제공한다. The present invention provides methods for preselecting TILs based on PD-1 expression, as well as methods for expanding those preselected PD-1 positiv...

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Bibliographic Details
Main Authors NATARAJAN ARVIND, CHARTIER COURTAUD CECILE, PAULSON MATT, SIMPSON ABELSON MICHELLE
Format Patent
LanguageKorean
Published 12.08.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:본 발명은 증강된 종양-특이적 사멸화 역량(capacity)(예를 들어, 증강된 세포독성)을 갖는 TIL의 치료 집단을 생성하기 위해 PD-1 발현에 기초하여 TIL을 예비선택하는 방법, 뿐만 아니라 이들 예비선택된 PD-1 양성 TIL을 확장시키는 방법을 제공한다. The present invention provides methods for preselecting TILs based on PD-1 expression, as well as methods for expanding those preselected PD-1 positive TILs in order to produce therapeutic populations of TILs with enhanced tumor-specific killing capacity (e.g., enhanced cytotoxicity).
Bibliography:Application Number: KR20217017219