포스포이노시티드 3-키나아제 (PI3K) 억제제의 결정질 형태

• Main Authors: BURNS DAVID M, COMBS ANDREW P, YUE EDDY W, DOUTY BRENT, JIA ZHONGJIANG, LEVY DANIEL
• Format: Patent
• Language: Korean
• Published: 21.07.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 암 및 다른 질환의 치료에 유용한 PI3K 억제제인, 2-(3-(8-아미노-6-(트리플루오로메틸)이미다조[1,2-a]피라진-3-일)-4-메틸페닐)-3,3,3-트리플루오로-2-히드록시프로판아미드의 염 및 결정질 형태, 8-아미노-N-(2-히드록시-2-메틸프로필)-3-(2-메틸-5-(1,1,1-트리플루오로-2-히드록시프로판-2-일)페닐)이미다조[1,2-a]피라진-6-카르복사미드의 결정질 형태, 및 8-아미노-N-(2-히드록시-2-메틸프로필)-3-(2-(메틸-d3)-5-(1,1,1-트리플루오로-2-히드록시프로판-2-일)페닐)이미다조[1,2-a]피라진-6-카르복사미드의 결정질 형태에 관한 것이다. The present invention relates to salts and crystalline forms of 2-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl)-4-methylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide, crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, and crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-(methyl-d3)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, which are PI3K inhibitors useful in the treatment of cancer and other diseases.