BCL-2-선택적 억제제로서의 트리플루오로메틸-치환된 술폰아미드

• Main Authors: ZHANG JIANQING, ZHU YIZHONG, LIU LIMIN, WANG JINAN, YANG LING, ZHANG XIQUAN, TANG XUJING, ZHANG HONGYING, TANG SONG, GU HONGMEI, WANG BIN, SHI WEI, FENG WEIWEI, YAO YIYAN, WANG SHANCHUN, LIU FEI, LI YANG, XU HONGJIANG, LIU YANLONG
• Format: Patent
• Language: Korean
• Published: 08.07.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

트리플루오로메틸-치환된 술폰아미드 BCL-2-선택적 억제제가 개시되며, 특히, 화학식 I의 화합물, 이의 입체 이성질체, 또는 이의 약학적으로 허용되는 염, 이의 제조 방법이 개시된다. 또한, 암과 같은 항-세포사멸 BCL-2-관련 질병을 치료하기 위한 상기 화합물 및 이를 포함하는 약학적 조성물의 용도가 개시된다. JPEGpct00509.jpg6455 Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.