나이트로소 화합물 및 퀴녹살린 화합물의 제조 방법

• Main Authors: TAMAI RYUJI, KOBAYASHI RYO, UCHIDA YUKIO, KATO AKIRA, MARUYAMA RYO, TAKABE FUMIAKI
• Format: Patent
• Language: Korean
• Published: 07.07.2021
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

하기 식 (3)의 나이트로소 화합물의 제조 방법으로서, 3급 알코올 및 염기를 이용함으로써, 하기 식 (1)의 화합물을 하기 식 (2)의 화합물과 반응시키는 것을 포함하는, 제조 방법: JPEGpct00072.jpg41151 (식 중, R1, R2, R3, R4, R5, R6, R7, R8 및 R9는, 각각 독립적으로, 수소 원자, 할로겐 원자, (C1-C4)알킬 또는 (C1-C4)알콕시이다). A method for producing a compound of a formula (3), including reacting a compound of a formula (1) with a compound of a formula (2) by using a tertiary alcohol and a base:where R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently a hydrogen atom, a halogen atom, a (C1-C4)alkyl, or a (C1-C4)alkoxy, the amount of the base used is 2.0-4.0 equivalents per 1 equivalent of the compound of formula (2), the amount of the tertiary alcohol used is 0.3-2.5 equivalents per 1 equivalent of the compound of formula (2), the base is a plurality of compounds comprising a lithium-containing base as a first compound, and a second compound selected from the group consisting of alkali metal hydrides, alkali metal amides, alkoxides, alkyl metals, alkali metals, and organic bases, and the reaction is performed in the presence of an aromatic hydrocarbon solvent.