오크로박트럼-매개 유전자 편집을 위한 조성물 및 방법

• Main Authors: BOLAR JYOTHI, CHO HYEON JE, LIU ZHAN BIN, CHANG SHUJUN
• Format: Patent
• Language: Korean
• Published: 07.07.2021
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

유전자 편집 효율을 증가시키거나, 개선하거나, 향상하기 위한 방법 및 조성물이 제공된다. 표적화된 게놈 변형의 효율을 개선시키는, 오크로박트럼 및 아그로박테륨계 벡터 성분, 예컨대, CRISPR Cas 엔도뉴클레아제 및 가이드 RNA의 입체배치가 제공된다. Methods and compositions for increasing, improving or enhancing gene editing efficiency are provided. Configurations of Ochrobactrum and Agrobacterium based vector components such as CRISPR Cas endonucleases and guide RNAs are provided that improve efficiency of targeted genome modification.