Microorganism including genetic modification that increases activity of multidrug efflux transport system and method for preparing tryptophan metabolites using the same

• Main Authors: BAE HYUN AE, RYU GYU RI, JANG JAE WOO, JEON AE JI
• Format: Patent
• Language: English; Korean
• Published: 30.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

다중약물 수송체 A(Multidrug efflux system subunit A: MdtA)의 활성을 증가시키는 유전적 변형(genetic modification)을 포함하는 재조합 미생물에 관한 것이다. 다중약물 수송체의 활성을 증가시키는 유전적 변형을 포함하는 재조합 미생물, 및 그를 이용한 트립토판 대사체를 생산하는 방법은 트립토판 대사체의 대량 생산을 가능하게 할 수 있다. Disclosed is a recombinant microorganism comprising a genetic modification that increases the activity of a multidrug transporter A (multidrug efflux system subunit A: MdtA). A recombinant microorganism comprising genetic modification that increases the activity of a multidrug transporter and a method for producing tryptophan metabolites by using same enable mass-production of tryptophan metabolites.