Novel indazole derivatives and use thereof

The present invention relates to a novel indazole derivative and a use thereof, and the indazole derivative has excellent TRIB2 or YAP inhibitory activity, and thus can be usefully used as a pharmaceutical composition for preventing or treating cancer, narcolepsy, and fasciitis. The present inventio...

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Bibliographic Details
Main Authors KIM SEONG HWAN, KIM PIL HO
Format Patent
LanguageEnglish
Korean
Published 24.06.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a novel indazole derivative and a use thereof, and the indazole derivative has excellent TRIB2 or YAP inhibitory activity, and thus can be usefully used as a pharmaceutical composition for preventing or treating cancer, narcolepsy, and fasciitis. The present invention relates to a compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof. 본 발명은 신규한 인다졸 유도체 및 이의 용도에 관한 것으로, 상기 인다졸 유도체는 TRIB2 또는 YAP 저해 활성이 우수하여 암, 기면증 및 근막염 예방 또는 치료용 약학 조성물로 유용하게 사용가능하다.
Bibliography:Application Number: KR20200176372