PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

• Main Authors: EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
• Format: Patent
• Language: English; Korean
• Published: 08.06.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본발명은 식 (I) 화합물의 MDM2 저해제를 제공하고, JPEGpat01305.jpg8258 (I) 여기서 변수들은 상기에서 정의되어 있고, 이 화합물은 특히 암의 치료를 위한 치료제로서 유용하다. 본발명은 또한 MDM2 저해제를 함유하는 약제학적 조성물에 관한 것이다. The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.