Novel quinoline compounds and uses thereof

• Main Authors: LEE MIN JI, KIM JUNGWON, HONG SIN HYOUNG, KIM GUN HWA, LEE JI HOON, MOON HO SANG, KU BOSUNG, NA DO HYEONG
• Format: Patent
• Language: English; Korean
• Published: 21.05.2021
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a novel quinoline compound and uses thereof and, more specifically, to a novel quinoline compound exhibiting CYP4A inhibitory activity and uses thereof for preventing, alleviating and treating metabolic diseases. The compound disclosed in the present invention has a remarkable CYP4A inhibitory effect, and exhibits activities such as promotion of glucose uptake into hepatocytes, inhibition of fat accumulation in hepatocytes, inhibition of reactive oxygen species caused by endoplasmic reticulum stress, and treatment of steatohepatitis, thereby being usefully used for development of therapeutic agents of metabolic diseases such as diabetes and fatty liver. 본 발명은 신규한 퀴놀린 화합물 및 이의 용도에 관한 것으로, CYP4A 저해 활성을 보이는 신규 퀴놀린 화합물 및 이의 대사질환의 예방, 개선, 치료용 용도에 관한 것이다. 본 발명에서 개시하는 화합물은 CYP4A 저해 효과가 현저하며 간세포로의 포도당 흡수 촉진, 간 세포에서의 지방 축적 억제, 소포체 스트레스에 의한 활성산소 억제, 지방간염 치료 등의 활성을 나타내어, 당뇨병 및 지방간 등 대사질환 치료제 개발에 매우 유용하게 활용될 수 있다.