IL-2 IL-2 RECEPTOR BINDING COMPOUNDS

• Main Authors: CWIRLA STEVEN E, DOWER WILLIAM J, BAKKER ALICE V, BARRETT RONALD W, NEEDELS MICHAEL C
• Format: Patent
• Language: English; Korean
• Published: 14.05.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 IL-2Rβ 리간드, IL-2Rγc 리간드 및 이러한 리간드를 포함하는 화합물에 관한 것이다. 리간드 및 화합물, 예컨대, IL-2Rβ 리간드 및/또는 IL-2Rγc 리간드를 포함하는 이종이량체 및 융합 단백질은 IL-2 수용체 작용제일 수 있다. An IL-2Ryc ligand comprising the amino acid sequence of Formula (12) (SEQ ID NO: 949) or a truncation analog of Formula (12) (SEQ ID NO: 949):- X171-X172-X173-X174-X175-C-X176-X177-X178-X179-X180-X181-X182-X183-C-X184-X185-X186-X187- X188-. X171 can be selected from D, E, G, H, K, M, N, P, Q, R, S, and T; X172 can be selected from A, D, E, G, I, K, L, P, Q, R, S, T, V, W, and Y; X173 can be selected from A, D, E, F, G, I, Q, S, T, V, W, and Y; X174 can be selected from V, A, I, E, I, L, M, N, Q, R, S, and T; X175 can be selected from V, A, E, I, L, M, N, Q, R, S, and T; X176 can be selected from Q, D, E, H, L, R, and V; X177 can be selected from D, E, N, T, and V; X178 can be selected from W, F, S, and Y; X179 can be selected from E, A, D, G, H, K, N, Q, R, and Y; X180 can be selected from G and R; X181 can be V; X182 can be selected from E, D, and Y; X183 can be selected from L, F, and I; X184 can be W; X185 can be selected from Q, C, H, I, L, P, T, V, and Y; X186 can be selected from A, D, E, G, M, R, S, T, and V; X187 can be selected from A, D, E, F, G, I, M, N, P, Q, R, S, T, V, W, and Y; and X188 can be selected from A, C, D, E, F, G, I, K, L, N, P, Q, R, S, and V.