CCR6 억제제로서 유용한 N-치환된-디옥소시클로부테닐아미노-3-히드록시-피콜린아미드

• Main Authors: UNWALLA RAYOMAND JAL, NUHANT PHILIPPE MARCEL, THORARENSEN ATLI, ROBINSON JR. RALPH PELTON, FLICK ANDREW CHRISTOPHER, KUNG DANIEL WEI SHUNG, TRUJILLO JOHN ISIDRO, MOUSSEAU JAMES JOHN, SCHMITT DANIEL COPLEY, GERSTENBERGER BRIAN STEPHEN, LOMBARDO VINCENT MICHAEL, SCHNUTE MARK EDWARD, WU HUIXIAN
• Format: Patent
• Language: Korean
• Published: 28.04.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 CC 케모카인 수용체 6 (CCR6)을 억제하는 화학식 (IA 및 1B)의 N-치환된-디옥소시클로부테닐아미노-3-히드록시-피콜린아미드 화합물 또는 그의 제약상 허용되는 염 또는 수화물, 이들 화합물을 함유하는 제약 조성물, 및 CCR6의 억제에 의해 호전되는 질환, 상태 또는 장애를 치료 또는 예방하기 위한 이들 화합물의 용도에 관한 것이다. The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B)or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.