MULTI SPECIFIC FUSION PROTEIN AND USE THEREOF

• Main Authors: RYU JAENAM, YANG SO YOUNG, JANG SEIL, LEE EUNJIN, KIMYOUNG, JANG CHANGHO, LEE JAEMIN, SONG YOUNGJA, BAEK GISUN, KIM HYE NAN, LEE HYUN MI, SONG JAEHO, YOON JAEBONG, KIM YEUNG CHUL, PARK YOUNG WOO, BAK JEONGHYEON, MOK JINKEOL, PARK BUM CHAN
• Format: Patent
• Language: English; Korean
• Published: 21.04.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a multispecific fusion protein that does not contain an Fc region and can specifically bind to two or more antigens. In one embodiment, a multispecific fusion protein comprising following structural formulas (I) and (II) is provided: N'-A-L1-X-C' (I); and N'-B-L1-Y-C' (II). The fusion protein may bind to cancer cells and immune cells, and may enhance the activity of immune cells. Therefore, the fusion protein can be used as an anticancer agent. 본 발명은 Fc 영역이 포함되지 않고, 두 개 이상의 항원에 특이적으로 결합할 수 있는 다중 특이적 융합 단백질을 제공한다. 일 구체예로 하기 구조식 (I) 및 (II)를 포함하는 다중 특이적 융합 단백질을 제공한다: N'-A-L1-X-C' (I); 및 N'-B-L1-Y-C' (II). 상기 융합 단백질은 암 세포와 면역세포에 결합할 수 있으며, 면역 세포의 활성을 증진시킬 수 있다. 따라서, 상기 융합 단백질은 항암제로 활용이 가능하다.