STING 효능제로서의 사이클릭 다이뉴클레오티드

• Main Authors: EDWARDS JAMES P, THATIKONDA SANTHOSH KUMAR, RICHTER MARK, EMANUEL STUART, VIELLEVOYE MARCEL, BEIGELMAN LEONID, THURING JOHANNES WILHELMUS J.F, CONNOLLY PETER J, BIGNAN GILLES, SCHEPENS WIM BERT GRIET, WANG GUANGYI
• Format: Patent
• Language: Korean
• Published: 25.03.2021
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

STING의 조절에 의해 영향을 받는 질병, 증후군 또는 장애를 치료하기 위한 화합물, 조성물 및 방법이 개시된다. 그러한 화합물은 화학식 (I)로 나타낸다: [화학식 (I)] JPEGpct00183.jpg4686 (상기 식에서, R1, R1',X1, B1, R2, R2',B2, X2, R3, Z-M-Y, 및 Y1-M1-Z1은 본 명세서에 정의된 바와 같음). Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.