TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS

• Main Authors: KANG LIN, ZEITLIN ANDREW, ZHANG XIAOKUI, VOSKINARIAN BERSE VANESSA A, PADLIYA NEERAV DILIP, PAL AJAI, HEIDARAN MOHAMMAD A
• Format: Patent
• Language: English; Korean
• Published: 02.03.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

태반 관류액, 태반 관류액 세포, 및 태반-유래 중간체 천연 킬러 (PINK) 세포, 및 그의 조합물을 본원에서 제공한다. 또한, 상기 물질을 포함하는 조성물, 및 종양 세포, 암 세포 등의 성장 또는 증식을 억제하고 종양 세포를 가진 개체를 치료하기 위해 태반 관류액, 태반 관류액 세포, 및 태반-유래 중간체 천연 킬러 세포, 및 그의 조합물을 사용하는 방법을 본원에서 제공한다. 바람직한 실시태양에서, 조성물은 단리된 CD56+, CD16- 천연 킬러 세포를 포함한다. The invention provides placental perfusate cells, CD56, CD16placental intermediate natural killer cells, and combinations of natural killer cells isolated from placental perfusate and natural killer cells isolated from umbilical cord blood which is isolated from the placenta from which said placental perfusate is obtained. Further provided herein are such cells and cell combinations for use in a method of suppressing the proliferation of tumor cells, in particular for the treatment of an individual having a tumor. Also provided herein are composition comprising isolated CD56, CD16natural killer cells which are isolated from placental perfusate and wherein the natural killer cells comprise at least 50% of cells in the composition.