암을 치료하기 위한 물질 및 방법

• Main Authors: KENDERIAN SAAD J, COX MICHELLE J, SAKEMURA REONA, STERNER ROSALIE M
• Format: Patent
• Language: Korean
• Published: 24.02.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 암 치료와 관련된 방법 및 물질을 제공한다. 예를 들어, GM-CSF의 수준이 감소된 키메라 항원 수용체 T 세포를 제공한다. 또한, GM-CSF의 수준이 감소된 키메라 항원 수용체 T 세포의 제조 및 이용 방법을 제공한다. This document provides methods and materials involved in treating cancer. For example, chimeric antigen receptor T cells having reduced levels of GM-CSF are provided. Also provided as methods for making and using chimeric antigen receptor T cells having reduced levels of GM-CSF.