TIE2 Anti-TIE2 antibody and Use Thereof

• Main Authors: PARK CHEONHO, YOO JIN SAN, PARK BEOM YONG, LEE WEON SUP, LEE EUN AH, KANG NU RI, LEE YOUNGAE, KIM DO YUN
• Format: Patent
• Language: English; Korean
• Published: 24.02.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to an antibody, which specifically binds to tyrosine-protein kinase receptor TIE-2 (TIE2) so as to possess functions of blood vessel normalization and stabilization through receptor phosphorylation. More particularly, the present invention relates to: an anti-TIE2 antibody; a nucleic acid encoding the same; a vector comprising the nucleic acid; a cell transformed with the vector; a method for preparing the antibody; an agent for stabilizing blood vessels and a composition for treating angiogenesis-associated diseases, both of which comprise the antibody; and a composition for co-administration with a pharmaceutical composition for tumor or cancer treatment and with a composition other than an antibody binding to TIE2. 본 발명은 TIE2 (Tyrosine-protein kinase receptor TIE-2)에 특이적으로 결합하여 수용체의 인산화를 통해 혈관을 정상화(vessel normalization)하고, 안정화 (stabilization)시키는 기능을 보유한 항체와 관련된 것으로, 항-TIE2 항체, 이를 코딩하는 핵산, 상기 핵산을 포함하는 벡터, 상기 벡터로 형질전환된 세포, 상기 항체의 제조방법, 이를 포함하는 혈관안정화제 및 신생혈관형성(angiogenesis)과 관련된 질병의 치료용 조성물, 종양 또는 암 치료용 약학적 조성물 및 TIE2에 결합하는 항체 이외의 조성물과의 병용투여용 조성물에 관한 것이다.