항체-회피 바이러스 벡터

• Main Authors: SMITH JAMES KENNON, BERRY GARRETT E, MCCOY DANIEL
• Format: Patent
• Language: Korean
• Published: 20.01.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 개시내용은 아미노산 서열에 변형을 포함하는 AAV 캡시드 단백질 및 변형된 AAV 캡시드 단백질을 포함하는 바이러스 벡터를 제공한다. 본 개시내용은 또한 생체내에서 본 개시내용의 바이러스 벡터 및 바이러스 캡시드를 세포 또는 대상체에게 투여하는 방법을 제공한다. The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.