TOPICAL LOCALIZED ISOXAZOLINE FORMULATION

• Main Authors: FUCHS STEFAN, HECKEROTH ANJA REGINA, MUELLER RAMONA, WILLIAMS HEIKE, ZOLLER HARTMUT
• Format: Patent
• Language: English; Korean
• Published: 24.12.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 이속사졸린 화합물 및 용매로서 N,N-디에틸-3-메틸벤즈아미드를 포함하는 제약상 또는 수의학상 허용되는 액체 담체 비히클을 포함하는 국소 적용 제제, 및 동물에서의 기생충 감염을 제어 및 예방하기 위한 향상된 방법을 제공한다. The disclosure relates to topical localized formulation for the treatment or prophylaxis of parasite infestation in animals by spot-on or pour-on administration, which comprises an effective amount of at least one isoxazoline compound of the Formula (I) and a pharmaceutically or veterinary acceptable liquid carrier vehicle comprising N,N-diethyl-3-methylbenzamide as a solvent; wherein the preferred veterinary acceptable liquid carrier further comprises a co-solvent of at least two of acetone, ethyl-L-lactate, dimethyl sulfoxide, dimethylacetamide and glycofurol. The most preferred isoxazoline compound disclosed is 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methyl-N-[(2,2,2-trifluoroethylcarbamoyl)-methyl]-benzamide.