OspA MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO

• Main Authors: COMSTEDT PAER, MEINKE ANDREAS, REINISCH CHRISTOPH, SCHUELER WOLFGANG, SCHLEGL ROBERT, LUNDBERG URBAN, GROHMANN BRIGITTE, WIZEL BENJAMIN, HANNER MARKUS
• Format: Patent
• Language: English; Korean
• Published: 17.12.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 외표면 단백질 A(OspA)의 돌연변이체 단편을 포함하는 폴리펩타이드, 이를 코딩하는 핵산, 상기 폴리펩타이드 및/또는 핵산을 포함하는 약제학적 조성물(특히 보렐리아 감염의 치료 또는 예방 방법에서 약제로서의 용도를 위한), 보렐리아 감염의 치료 또는 예방 방법 및 대상체의 면역화 방법에 관한 것이다. The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a vector or host cell comprsing the same, a method of producing the polypeptide, a pharmaceutical comprising the polypeptide and/or the nucleic acid and the polypeptide or pharmaceutical composition for use as a medicament or for use in a method of treating or preventing aBorreliainfection.