AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN

• Main Authors: THOMPSON SCOTT KEVIN, PRIESTLEY TONY, SMITH ROGER ASTBURY, BEHRENS CARL HENRY, HAJRA ARUN KUMA, CHATTERJEE DIPANWITA, HE YIGANG, LI HUI YIN, SAHA ASHIS K, RUDRA SONALI
• Format: Patent
• Language: English; Korean
• Published: 04.11.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 출원은 신규 아미노인단 화합물 및 이들 화합물의 제조 및 사용 방법을 제공한다. 이들 화합물은 환자에게 하나 이상의 화합물을 투여함으로써 환자의 통증 및/또는 가려움을 치료하는 것에 유용하다. 해당 방법은 화학식 (I) 또는 (II)의 화합물 및 TRPV1 수용체 활성제를 투여하는 단계를 포함한다. 일 실시형태에서, TRPV1 수용체 활성제는 리도카인이다. The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.