STT2-5-Methyl-4-oxo-2-thioxo-13-thiazolidin-3-yl ethanesulfonic acid pharmaceutical composition for treating or preventing Parkinson's disease comprising STT as an active ingredient

• Main Authors: NAM SEUNG YOON, JEONG JOO WON, LEE JINHYUK, YU SEOK JONG
• Format: Patent
• Language: English; Korean
• Published: 28.10.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The present invention relates to a pharmaceutical composition for treating or preventing Parkinson′s disease containing a 2-(5-methyl-4-oxo-2-thioxo-1,3-thiazolidin-3-yl) ethanesulfonic acid (STT) compound as an active component. STT exhibits a neuroprotective effect and an apoptosis recovery effect in a Parkinson′s disease cell model, and exhibits to recover decreased motility and significantly protect dopamine cells in a MPTP animal model, thereby being able to be used for prevention and treatment of Parkinson′s disease. 본 발명은 STT화합물을 유효성분으로 포함하는 파킨슨 질환 치료 또는 예방용 약학적 조성물에 관한 것이다. STT는 파킨슨병 세포 모델에서 신경 보호 효과와 세포 사멸 회복 효과를 나타냈으며, MPTP 동물모델에서도 저하된 운동성이 회복되고 도파민 세포를 현저히 보호하는 것으로 나타나 파킨슨병의 예방 및 치료 용도로 이용 가능하다.