ORAL SOLID FORMULATION COMPRISING PYRIDOPYRIMIDIN-BASED HYDROCHLORIDE AND PREPARATION METHOD THEREOF

The present invention can provide a solid preparation for oral administration with excellent stability and drug dissolution rate due to the combined use of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidine-5(6H)-on hydrochloride with a specific carrier. Furtherm...

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Bibliographic Details
Main Authors CHOI JANG SIK, PARK SONG EUN, LEE HEE KYU, PARK SUNG HO, KIM JUNG HO, CHOI YUNG GEUN, JUNG DONG SIK
Format Patent
LanguageEnglish
Korean
Published 11.08.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention can provide a solid preparation for oral administration with excellent stability and drug dissolution rate due to the combined use of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidine-5(6H)-on hydrochloride with a specific carrier. Furthermore, the solid preparation for oral administration can be usefully commercialized as a pharmaceutical composition for the treatment of proliferative diseases. 본 발명은 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-펜옥시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염을 특정 담체와 함께 사용하여 안정성 및 약물 용출률이 우수한 경구용 고형제제를 제공할 수 있다. 나아가, 상기 경구용 고형제제는 증식성 질환의 치료를 위한 약제학적 조성물로 유용하게 상용화할 수 있다.
Bibliography:Application Number: KR20190013982